Aberrant Expression and Glycosylation of Mucins in Gastric Mucosal Disease / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 294-298, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-927878
ABSTRACT
Mucins,a family of heavily glycosylated proteins,present mainly in epithelial cells.They function as essential barriers for epithelium and play important roles in cellular physiological processes.Aberrant expression and glycosylation of mucins in gastric epithelium occur at pathological conditions,such as Helicobacter pylori infection,chronic atrophic gastritis,intestinal metastasis,dysplasia,and gastric cancer.This review addresses the major roles played by mucins and associated O-glycan structures in normal gastric epithelium.Further,we expound the alterations of expression patterns and glycan signatures of mucins at those pathological conditions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stomach Neoplasms
/
Glycosylation
/
Helicobacter pylori
/
Helicobacter Infections
/
Gastric Mucosa
/
Mucins
Limits:
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2022
Type:
Article
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