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Quality value transmitting of substance benchmarks in Danggui Buxue Decoction / 中国中药杂志
Article in Chinese | WPRIM | ID: wpr-927974
Responsible library: WPRO
ABSTRACT
To clarify the key quality attributes of substance benchmarks in Danggui Buxue Decoction(DBD), this study prepared 21 batches of DBD substance benchmarks, and established two methods for detecting their fingerprints, followed by the identification of peak attribution and similarity range as well as the determination of extract and transfer rate ranges and contents of index components ferulic acid, calycosin-7-O-β-D-glucoside, and astragaloside Ⅳ. The mass fractions and transfer rates of DBD substance benchmarks from different batches were calculated as follows ferulic acid(index component in Angelicae Sinensis Radix) 0.037%-0.084% and 31.41%-98.88%; astragaloside Ⅳ(index component in Astragali Radix) 0.021%-0.059% and 32.18%-118.57%; calycosin-7-O-β-D-glucoside 0.002%-0.023% and 11.51%-45.65%, with the extract rate being 18.4%-36.1%. The similarity of fingerprints among 21 batches of DBD substance benchmarks was all higher than 0.9. The quality control method for DBD substance benchmarks was preliminarily established based on the HPLC fingerprint analysis and index component determination, which has provided a basis for the subsequent development of DBD and the quality control of novel related preparations.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality Control / Drugs, Chinese Herbal / Chromatography, High Pressure Liquid Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality Control / Drugs, Chinese Herbal / Chromatography, High Pressure Liquid Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2022 Type: Article