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Preparation and in vitro release of quercetin nanocrystals self-stabilized Pickering emulsion / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1230-1236, 2022.
Article in Chinese | WPRIM | ID: wpr-928047
ABSTRACT
A new quercetin nanocrystals self-stabilized Pickering emulsion(QT-NSSPE) was prepared by high-pressure homogenization combined with probe ultrasonic method. The influences of oil fraction, quercetin(QT) concentration, and pH of water phase on the formation of QT-NSSPE were investigated. On this basis, the QT-NSSPE prepared under optimal conditions was evaluated in terms of microstructure, stability, and in vitro release and the droplet size and drug loading were 15.82 μm and 4.87 mg·mL~(-1), respectively. The shell structure formed by quercetin nanocrystals(QT-NC) on the emulsion droplet surface was observed under a scanning electron microscope(SEM). X-ray diffraction(XRD) showed that the crystallinity of adsorbed QT-NC decreased significantly as compared with the raw QT. There were not significant changes of QT-NSSPE properties after 30 days of storage at room temperature. The in vitro release experiment confirmed that QT-NSSPE has a higher accumulative release rate than the raw QT. All these results indicated that QT-NSSPE has a great stability and a satisfactory in vitro release behavior, which is a promising new oral delivery system for QT.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Particle Size / Quercetin / Water / Emulsions / Nanoparticles Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Particle Size / Quercetin / Water / Emulsions / Nanoparticles Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2022 Type: Article