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Secondary metabolites of endophyte fungi Xylaria sp. from Coptis chinensis / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 2165-2169, 2022.
Article in Chinese | WPRIM | ID: wpr-928156
ABSTRACT
Two new polyketides, lasobutone A(1) and lasobutone B(2), along with three known compounds, guignardianone C(3), guignardic acid(4), and 4-hydroxy-17R-methylincisterol(5), were isolated from the endophytic fungi Xylaria sp. by silica gel, MCI, and preparative HPLC, which was separated from the Chinese medicinal material Coptis chinensis and cultivated through solid fermentation with rice. Their structures were elucidated on the basis of spectroscopic methods, such as MS, NMR, IR, UV, and ECD. Compounds 2 and 4 showed inhibitory activities against the nitric oxide(NO) production in the LPS-induced macrophage RAW264.7 with IC_(50) values of 58.7 and 42.5 μmol·L~(-1) respectively, while compound 5 exhibited cytotoxic activities against HT-29 with IC_(50) value of 14.3 μmol·L~(-1).
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Endophytes / Polyketides / Fungi / Coptis chinensis / Antineoplastic Agents Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Endophytes / Polyketides / Fungi / Coptis chinensis / Antineoplastic Agents Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2022 Type: Article