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Analysis of RS1 gene variant in a Chinese pedigree affected with X-linked congenital retinal splitters / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 378-382, 2022.
Article in Chinese | WPRIM | ID: wpr-928423
ABSTRACT
OBJECTIVE@#To explore the genetic basis for a Chinese pedigree affected with X-linked retinoschisis.@*METHODS@#Clinical data of the pedigree was collected. Following DNA extraction, PCR and Sanger sequencing were carried out to detect potential variant in the RS1 gene. The result was verified by using PCR and restriction fragment length polymorphism assay.@*RESULTS@#All male patients were found to harbor a c.458T>G (p.Val153Gly) variant of the RS1 gene, for which Their mothers were heterozygous carriers. The same variant was not detected among unaffected members of the pedigree as well as 100 healthy controls. Bioinformatic analysis suggested the variant to be pathogenic.@*CONCLUSION@#The c.458T>G (p.Val153Gly) variant of the RS1 gene probably underlay the X-linked retinoschisis in this pedigree.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pedigree / China / Retinoschisis / Genes, X-Linked / Eye Proteins / Mutation Limits: Humans / Male Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pedigree / China / Retinoschisis / Genes, X-Linked / Eye Proteins / Mutation Limits: Humans / Male Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2022 Type: Article