Fungal periprosthetic joint infection: Rare but challenging problem / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 63-66, 2022.
Article
in English
| WPRIM
| ID: wpr-928490
ABSTRACT
Periprosthetic joint infection (PJI) is the most difficult complication following total joint arthroplasty. Most of the etiological strains, accounting for over 98% of PJI, are bacterial species, with Staphylococcusaureus and Coagulase-negative staphylococci present in between 50% and 60% of all PJIs. Fungi, though rare, can also cause PJI in 1%-2% of cases and can be challenging to manage. The management of this uncommon but complex condition is challenging due to the absence of a consistent algorithm. Diagnosis of fungal PJI is difficult as isolation of the organisms by traditional culture may take a long time, and some of the culture-negative PJI can be caused by fungal organisms. In recent years, the introduction of next-generation sequencing has provided opportunity for isolation of the infective organisms in culture-negative PJI cases. The suggested treatment is based on consensus and includes operative and non-operative measures. Two-stage revision surgery is the most reliable surgical option for chronic PJI caused by fungi. Pharmacological therapy with antifungal agents is required for a long period of time with antibiotics and included to cover superinfections with bacterial species. The aim of this review article is to report the most up-to-date information on the diagnosis and treatment of fungal PJI with the intention of providing clear guidance to clinicians, researchers and surgeons.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis, Infectious
/
Retrospective Studies
/
Prosthesis-Related Infections
/
Arthroplasty, Replacement, Knee
/
Fungi
Type of study:
Practice guideline
/
Observational study
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Traumatology
Year:
2022
Type:
Article
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