Human umbilical cord Wharton's jelly-derived mesenchymal stem cell transplantation could improve diabetic intracavernosal pressure / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 171-175, 2022.
Article
in English
| WPRIM
| ID: wpr-928501
ABSTRACT
Mesenchymal stem cells (MSCs) secrete various cytokines with angiogenic and neuroprotective effects. This study aimed to assess the effects of human umbilical cord Wharton's jelly-derived MSCs (hWJ-MSCs) on diabetes-related intracavernosal pressure (ICP) impairment in rats. hWJ-MSCs were isolated from human umbilical cord Wharton's jelly and transplanted into the corpus cavernosum of streptozotocin (STZ)-induced diabetic rats by unilateral injection. The erectile function was evaluated at 4 weeks, as well as the expression levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), endothelial nitric oxide synthase (eNOS), and insulin-like growth factor 1 (IGF1). STZ-induced diabetic rats showed impaired ICP, which was significantly improved by hWJ-MSC treatment. VEGF, eNOS, IGF1, and bFGF expression levels were higher in hWJ-MSC injection sites than those in control ones in STZ-induced diabetic rats. These results suggest that hWJ-MSC transplantation might improve diabetic erectile dysfunction through increased production of paracrine growth factors, highlighting a novel potential therapeutic option for erectile dysfunction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Umbilical Cord
/
Cell Differentiation
/
Vascular Endothelial Growth Factor A
/
Mesenchymal Stem Cell Transplantation
/
Diabetes Mellitus, Experimental
/
Wharton Jelly
/
Erectile Dysfunction
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Asian Journal of Andrology
Year:
2022
Type:
Article
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