The roles of intraflagellar transport (IFT) protein 25 in mammalian signaling transduction and flagellogenesis / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 238-242, 2022.
Article
in English
| WPRIM
| ID: wpr-928542
ABSTRACT
Cilium, an organelle with a unique proteome and organization, protruding from the cell surface, generally serves as a force generator and signaling compartment. During ciliogenesis, ciliary proteins are synthesized in cytoplasm and transported into cilia by intraflagellar transport (IFT) particles, where the inner counterparts undergo reverse trafficking. The homeostasis of IFT plays a key role in cilial structure assembly and signaling transduction. Much progress has been made on the mechanisms and functions of IFT; however, recent studies have revealed the involvement of IFT particle subunits in organogenesis and spermatogenesis. In this review, we discuss new concepts concerning the molecular functions of IFT protein IFT25 and how its interactions with other IFT particle subunits are involved in mammalian development and fertility.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biological Transport
/
Signal Transduction
/
Proteins
/
Carrier Proteins
/
Cilia
/
Organogenesis
/
Flagella
/
Mammals
Limits:
Animals
Language:
English
Journal:
Asian Journal of Andrology
Year:
2022
Type:
Article
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