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Targeted Therapy and Mechanism of Drug Resistance in Non-small Cell Lung Cancer 
with Epidermal Growth Factor Receptor Gene Mutation / 中国肺癌杂志
Chinese Journal of Lung Cancer ; (12): 183-192, 2022.
Article in Chinese | WPRIM | ID: wpr-928796
ABSTRACT
Lung cancer is the sixth leading cause of death worldwide and one of the leading cause of death from malignant tumors. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Epidermal growth factor receptor (EGFR) gene mutation is a common mutation in NSCLC. For advanced NSCLC patients with EGFR mutations, EGFR-tyrosine kinase inhibitors (EGFR-TKIs), such as Gefitinib, Afatinib, Oxitinib and other targeted therapies have become the first-line treatment recommended by many guidelines, but many patients develop acquired drug resistance after about 1 year of medication. Patients with drug resistance will have earlier disease progression than patients without drug resistance, which has an important impact on the prognosis of patients. At present, the main treatment for patients with acquired resistance is new target inhibition for resistant mutation. For example, if patients with T790M mutation are resistant to the first or second generation drugs such as Gefitinb and Afatinib, they can be treated with the third generation drugs (Osimertinib or Almonertinib), which can delay the progression of the disease. Therefore, the study of drug resistance mechanism and treatment of drug resistance patients are essential. This paper mainly reviews targeted therapy and drug resistance mechanism of EGFR-mutant NSCLC patients, in order to provide reference for clinical application of EGFR-TKIs.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pyrimidines / Acrylamides / Carcinoma, Non-Small-Cell Lung / Genes, erbB-1 / Drug Resistance, Neoplasm / Protein Kinase Inhibitors / ErbB Receptors / Indoles / Lung Neoplasms / Mutation Type of study: Practice guideline / Prognostic study Limits: Humans Language: Chinese Journal: Chinese Journal of Lung Cancer Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pyrimidines / Acrylamides / Carcinoma, Non-Small-Cell Lung / Genes, erbB-1 / Drug Resistance, Neoplasm / Protein Kinase Inhibitors / ErbB Receptors / Indoles / Lung Neoplasms / Mutation Type of study: Practice guideline / Prognostic study Limits: Humans Language: Chinese Journal: Chinese Journal of Lung Cancer Year: 2022 Type: Article