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Applications of QSAR in Toxicological Risk Assessment of Medical Devices / 中国医疗器械杂志
Chinese Journal of Medical Instrumentation ; (6): 200-205, 2022.
Article in Chinese | WPRIM | ID: wpr-928888
ABSTRACT
The chemical characterization analysis of a medical device often results in chemical substances with unknown toxicities. While identification of each individual toxicity could result in a time-consuming hurdle with tremendous labor and financial burden, quantitative structure-activity relationship (QSAR) is of great significance for toxicity risk assessment of such chemical substances. By establishing quantitative relationship between the molecular structures or active groups of similar chemical compounds with their biological activities, QSAR can be utilized to predict the toxicity of such target compounds with significantly reduced cost and time. In this article, the authors generally summarized the mechanisms of QSAR approaches, current applications of QSAR modeling in the field of medical device, an introduction of the characteristics of publicly and commercially-available QSAR software, and briefly explored future trends of QSAR modeling in medical device toxicological risk assessment. The utilization of QSAR would undoubtedly further advance the toxicological risk assessment of medical devices.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Software / Risk Assessment / Quantitative Structure-Activity Relationship Type of study: Etiology study / Prognostic study / Risk factors Language: Chinese Journal: Chinese Journal of Medical Instrumentation Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Software / Risk Assessment / Quantitative Structure-Activity Relationship Type of study: Etiology study / Prognostic study / Risk factors Language: Chinese Journal: Chinese Journal of Medical Instrumentation Year: 2022 Type: Article