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Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B ; (12): 89-101, 2022.
Article in English | WPRIM | ID: wpr-929042
ABSTRACT
Cancer is the leading cause of death worldwide. Drugs play a pivotal role in cancer treatment, but the complex biological processes of cancer cells seriously limit the efficacy of various anticancer drugs. Autophagy, a self-degradative system that maintains cellular homeostasis, universally operates under normal and stress conditions in cancer cells. The roles of autophagy in cancer treatment are still controversial because both stimulation and inhibition of autophagy have been reported to enhance the effects of anticancer drugs. Thus, the important question arises as to whether we should try to strengthen or suppress autophagy during cancer therapy. Currently, autophagy can be divided into four main forms according to its different functions during cancer treatment cytoprotective (cell survival), cytotoxic (cell death), cytostatic (growth arrest), and nonprotective (no contribution to cell death or survival). In addition, various cell death modes, such as apoptosis, necrosis, ferroptosis, senescence, and mitotic catastrophe, all contribute to the anticancer effects of drugs. The interaction between autophagy and these cell death modes is complex and can lead to anticancer drugs having different or even completely opposite effects on treatment. Therefore, it is important to understand the underlying contexts in which autophagy inhibition or activation will be beneficial or detrimental. That is, appropriate therapeutic strategies should be adopted in light of the different functions of autophagy. This review provides an overview of recent insights into the evolving relationship between autophagy and cancer treatment.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Autophagy / Apoptosis / Necrosis / Neoplasms / Antineoplastic Agents Limits: Humans Language: English Journal: Journal of Zhejiang University. Science. B Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Autophagy / Apoptosis / Necrosis / Neoplasms / Antineoplastic Agents Limits: Humans Language: English Journal: Journal of Zhejiang University. Science. B Year: 2022 Type: Article