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Chemerin promotes proliferation and migration of ovarian cancer cells by upregulating expression of PD-L1 / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B ; (12): 164-170, 2022.
Article in English | WPRIM | ID: wpr-929048
ABSTRACT
Ovarian cancer is the third-most-common malignant reproductive tumor in women. According to the American Cancer Society, it has the highest mortality rate of gynecological tumors. The five-year survival rate was only 29% during the period from 1975 to 2008 (Reid et al., 2017). In recent decades, the five-year survival rate of ovarian cancer has remained around 30% despite continuous improvements in surgery, chemotherapy, radiotherapy, and other therapeutic methods. However, because of the particularity of the volume and location of ovarian tissue, the early symptoms of ovarian cancer are hidden, and there is a lack of highly sensitive and specific screening methods. Most patients have advanced metastasis, including abdominal metastasis, when they are diagnosed (Reid et al., 2017). Therefore, exploring the mechanism of ovarian cancer metastasis and finding early preventive measures are key to improving the survival rate and reducing mortality caused by ovarian cancer.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Ovarian Neoplasms / Up-Regulation / Survival Rate / Chemokines / Cell Proliferation / B7-H1 Antigen Limits: Female / Humans Language: English Journal: Journal of Zhejiang University. Science. B Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Ovarian Neoplasms / Up-Regulation / Survival Rate / Chemokines / Cell Proliferation / B7-H1 Antigen Limits: Female / Humans Language: English Journal: Journal of Zhejiang University. Science. B Year: 2022 Type: Article