Your browser doesn't support javascript.
loading
Effects of administration of IH901, a ginsenoside intestinal metabolite, on muscular and pulmonary antioxidant functions after eccentric exercise
Journal of Veterinary Science ; : 249-256, 2013.
Article in English | WPRIM | ID: wpr-92907
ABSTRACT
This study was conducted to investigate whether administration of IH901, a ginseng intestinal metabolite, ameliorates exercise-induced oxidative stress while preserving antioxidant defense capability in rat skeletal muscles and lung. Eight adult male Sprague-Dawley rats per group were randomly assigned to the resting control, exercise control, resting with IH901 (25, 50, and 100 mg/kg) consumption (R/IH901), or exercise with IH901 (25, 50, and 100 mg/kg) consumption (E/IH901) group. The trained groups ran 35 min 2 days/week for 8 weeks. To analyze the IH901-training interaction, serum biochemical analysis, lipid peroxidation, citrate synthase, protein oxidation, antioxidant and superoxide dismutase in skeletal muscles and lung tissue were measured. Compared to the exercise control group, animals that consumed IH901 had significantly increased exercise endurance times (p < 0.05) and decreased plasma creatine kinase and lactate dehydrogenase levels (p < 0.05), while those in the E/IH901 groups had increased citrate synthase and anti-oxidant enzymes and decreased lipid peroxidation and protein oxidation (p < 0.05). In conclusion, IH901 consumption in aging rats after eccentric exercise has beneficial effects on anti-inflammatory and anti-oxidant activities through down-regulation of pro-inflammatory mediators, lipid peroxidation, and protein oxidation and up-regulation of anti-oxidant enzymes.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Physical Conditioning, Animal / Sapogenins / Aging / Rats, Sprague-Dawley / Specific Pathogen-Free Organisms / Oxidative Stress / Muscle, Skeletal / Dose-Response Relationship, Drug / Panax / Lung Limits: Animals Language: English Journal: Journal of Veterinary Science Year: 2013 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Physical Conditioning, Animal / Sapogenins / Aging / Rats, Sprague-Dawley / Specific Pathogen-Free Organisms / Oxidative Stress / Muscle, Skeletal / Dose-Response Relationship, Drug / Panax / Lung Limits: Animals Language: English Journal: Journal of Veterinary Science Year: 2013 Type: Article