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Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes / 神经科学通报·英文版
Neuroscience Bulletin ; (6): 47-68, 2022.
Article in English | WPRIM | ID: wpr-929080
ABSTRACT
Human cortical radial glial cells are primary neural stem cells that give rise to cortical glutaminergic projection pyramidal neurons, glial cells (oligodendrocytes and astrocytes) and olfactory bulb GABAergic interneurons. One of prominent features of the human cortex is enriched with glial cells, but there are major gaps in understanding how these glial cells are generated. Herein, by integrating analysis of published human cortical single-cell RNA-Seq datasets with our immunohistochemistical analyses, we show that around gestational week 18, EGFR-expressing human cortical truncated radial glial cells (tRGs) give rise to basal multipotent intermediate progenitors (bMIPCs) that express EGFR, ASCL1, OLIG2 and OLIG1. These bMIPCs undergo several rounds of mitosis and generate cortical oligodendrocytes, astrocytes and olfactory bulb interneurons. We also characterized molecular features of the cortical tRG. Integration of our findings suggests a general picture of the lineage progression of cortical radial glial cells, a fundamental process of the developing human cerebral cortex.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Cell Differentiation / Cerebral Cortex / Oligodendroglia / Neuroglia / Astrocytes Limits: Humans Language: English Journal: Neuroscience Bulletin Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Cell Differentiation / Cerebral Cortex / Oligodendroglia / Neuroglia / Astrocytes Limits: Humans Language: English Journal: Neuroscience Bulletin Year: 2022 Type: Article