Polysaccharide Krestin Prevents Alzheimer's Disease-type Pathology and Cognitive Deficits by Enhancing Monocyte Amyloid-β Processing / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 290-302, 2022.
Article
in En
| WPRIM
| ID: wpr-929083
Responsible library:
WPRO
ABSTRACT
Deficits in the clearance of amyloid β protein (Aβ) by the peripheral system play a critical role in the pathogenesis of sporadic Alzheimer's disease (AD). Impaired uptake of Aβ by dysfunctional monocytes is deemed to be one of the major mechanisms underlying deficient peripheral Aβ clearance in AD. In the current study, flow cytometry and biochemical and behavioral techniques were applied to investigate the effects of polysaccharide krestin (PSK) on AD-related pathology in vitro and in vivo. We found that PSK, widely used in therapy for various cancers, has the potential to enhance Aβ uptake and intracellular processing by human monocytes in vitro. After administration of PSK by intraperitoneal injection, APP/PS1 mice performed better in behavioral tests, along with reduced Aβ deposition, neuroinflammation, neuronal loss, and tau hyperphosphorylation. These results suggest that PSK holds promise as a preventive agent for AD by strengthening the Aβ clearance by blood monocytes and alleviating AD-like pathology.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Polysaccharides
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Proteoglycans
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Mice, Transgenic
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Monocytes
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Amyloid beta-Peptides
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Amyloid beta-Protein Precursor
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Cognition
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Disease Models, Animal
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Alzheimer Disease
Limits:
Animals
Language:
En
Journal:
Neuroscience Bulletin
Year:
2022
Type:
Article