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Dissecting the Neural Circuitry for Pain Modulation and Chronic Pain: Insights from Optogenetics / 神经科学通报·英文版
Neuroscience Bulletin ; (6): 440-452, 2022.
Article in English | WPRIM | ID: wpr-929115
ABSTRACT
Pain is an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage. The processing of pain involves complicated modulation at the levels of the periphery, spinal cord, and brain. The pathogenesis of chronic pain is still not fully understood, which makes the clinical treatment challenging. Optogenetics, which combines optical and genetic technologies, can precisely intervene in the activity of specific groups of neurons and elements of the related circuits. Taking advantage of optogenetics, researchers have achieved a body of new findings that shed light on the cellular and circuit mechanisms of pain transmission, pain modulation, and chronic pain both in the periphery and the central nervous system. In this review, we summarize recent findings in pain research using optogenetic approaches and discuss their significance in understanding the pathogenesis of chronic pain.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spinal Cord / Brain / Chronic Pain / Optogenetics / Neurons Limits: Humans Language: English Journal: Neuroscience Bulletin Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spinal Cord / Brain / Chronic Pain / Optogenetics / Neurons Limits: Humans Language: English Journal: Neuroscience Bulletin Year: 2022 Type: Article