Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 403-416, 2022.
Article
in En
| WPRIM
| ID: wpr-929123
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WPRO
ABSTRACT
Spinal cord stimulation (SCS)-induced analgesia was characterized, and its underlying mechanisms were examined in a spared nerve injury model of neuropathic pain in rats. The analgesic effect of SCS with moderate mechanical hypersensitivity was increased with increasing stimulation intensity between the 20% and 80% motor thresholds. Various frequencies (2, 15, 50, 100, 10000 Hz, and 2/100 Hz dense-dispersed) of SCS were similarly effective. SCS-induced analgesia was maintained without tolerance within 24 h of continuous stimulation. SCS at 2 Hz significantly increased methionine enkephalin content in the cerebrospinal fluid. The analgesic effect of 2 Hz was abolished by μ or κ opioid receptor antagonist. The effect of 100 Hz was prevented by a κ antagonist, and that of 10 kHz was blocked by any of the μ, δ, or κ receptor antagonists, suggesting that the analgesic effect of SCS at different frequencies is mediated by different endorphins and opioid receptors.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Spinal Cord
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Receptors, Opioid
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Receptors, Opioid, kappa
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Opioid Peptides
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Spinal Cord Stimulation
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Analgesics
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Narcotic Antagonists
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Neuralgia
Limits:
Animals
Language:
En
Journal:
Neuroscience Bulletin
Year:
2022
Type:
Article