Your browser doesn't support javascript.
loading
Loss of KDM4B impairs osteogenic differentiation of OMSCs and promotes oral bone aging / 国际口腔科学杂志·英文版
International Journal of Oral Science ; (4): 24-24, 2022.
Article in English | WPRIM | ID: wpr-929152
ABSTRACT
Aging of craniofacial skeleton significantly impairs the repair and regeneration of trauma-induced bony defects, and complicates dental treatment outcomes. Age-related alveolar bone loss could be attributed to decreased progenitor pool through senescence, imbalance in bone metabolism and bone-fat ratio. Mesenchymal stem cells isolated from oral bones (OMSCs) have distinct lineage propensities and characteristics compared to MSCs from long bones, and are more suited for craniofacial regeneration. However, the effect of epigenetic modifications regulating OMSC differentiation and senescence in aging has not yet been investigated. In this study, we found that the histone demethylase KDM4B plays an essential role in regulating the osteogenesis of OMSCs and oral bone aging. Loss of KDM4B in OMSCs leads to inhibition of osteogenesis. Moreover, KDM4B loss promoted adipogenesis and OMSC senescence which further impairs bone-fat balance in the mandible. Together, our data suggest that KDM4B may underpin the molecular mechanisms of OMSC fate determination and alveolar bone homeostasis in skeletal aging, and present as a promising therapeutic target for addressing craniofacial skeletal defects associated with age-related deteriorations.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteogenesis / Osteoporosis / Aging / Cell Differentiation / Facial Bones / Jumonji Domain-Containing Histone Demethylases / Mesenchymal Stem Cells Limits: Humans Language: English Journal: International Journal of Oral Science Year: 2022 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteogenesis / Osteoporosis / Aging / Cell Differentiation / Facial Bones / Jumonji Domain-Containing Histone Demethylases / Mesenchymal Stem Cells Limits: Humans Language: English Journal: International Journal of Oral Science Year: 2022 Type: Article