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Three new ursane-type triterpenoids from Rosmarinus officinalis and their biological activities / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 155-160, 2022.
Article in English | WPRIM | ID: wpr-929246
ABSTRACT
Three new ursane-type triterpenoids, 3-oxours-12-en-20, 28-olide (1), 3β-hydroxyurs-12-en-20, 28-olide (2) and 3β-hydroxyurs-11, 13(18)-dien-20, 28-olide (3), were isolated from a potent anti-inflammatory and antibacterial fraction of the ethanolic extract of Rosmarinus officinalis. Their structures were elucidated by a combination of extensive 1D- and 2D-NMR experiments, MS data and comparisons with literature reports. Compounds 1-3 exhibited significantly inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages, but no antibacterial activity was found at a concentration of 128 μg·mL-1.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Triterpenes / Drugs, Chinese Herbal / Molecular Structure / Rosmarinus Limits: Animals Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Triterpenes / Drugs, Chinese Herbal / Molecular Structure / Rosmarinus Limits: Animals Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2022 Type: Article