Sesquiterpenoids from the leaves of Sarcandra glabra / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 215-220, 2022.
Article
in English
| WPRIM
| ID: wpr-929254
ABSTRACT
Sarglanoids A-F, six new sesquiterpenoids belonging to eudesmane (1-5) and eremophilane (6) types, were isolated from the leaves of Sarcandra glabra, a famous traditional Chinese medicine (TCM). Their structures including absolute configurations were elucidated through extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Compounds 1-2 were rare N-containing eudesmane-type sesquiterpenoids. Compound 3 exhibited inhibitory activity against nitric oxide (NO) production in lipopolysaccharides (LPS)-induced RAW 264.7 cells with IC50 values at 20.00 ± 1.30 μmol·L-1. These findings provide scientific evidence for sesquiterpenoids as the material foundation of S. glabra.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Seeds
/
Sesquiterpenes
/
Molecular Structure
/
Plant Leaves
/
Polycyclic Sesquiterpenes
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2022
Type:
Article
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