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Promising natural lysine specific demethylase 1 inhibitors for cancer treatment: advances and outlooks / 中国天然药物
Article in En | WPRIM | ID: wpr-929257
Responsible library: WPRO
ABSTRACT
Lysine specific demethylase 1 (LSD1), a transcriptional corepressor or coactivator that serves as a demethylase of histone 3 lysine 4 and 9, has become a potential therapeutic target for cancer therapy. LSD1 mediates many cellular signaling pathways and regulates cancer cell proliferation, invasion, migration, and differentiation. Recent research has focused on the exploration of its pharmacological inhibitors. Natural products are a major source of compounds with abundant scaffold diversity and structural complexity, which have made a major contribution to drug discovery, particularly anticancer agents. In this review, we briefly highlight recent advances in natural LSD1 inhibitors over the past decade. We present a comprehensive review on their discovery and identification process, natural plant sources, chemical structures, anticancer effects, and structure-activity relationships, and finally provide our perspective on the development of novel natural LSD1 inhibitors for cancer therapy.
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Full text: 1 Index: WPRIM Main subject: Enzyme Inhibitors / Histone Demethylases / Lysine / Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2022 Type: Article
Full text: 1 Index: WPRIM Main subject: Enzyme Inhibitors / Histone Demethylases / Lysine / Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2022 Type: Article