Advances in self-assembled peptide hydrogels for bone regeneration / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 356-364, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-929475
ABSTRACT
@#The development of osteoinductive bone-filling biomaterials for bone regeneration is of great significance.Self-assembled peptide hydrogels with high biomimetic extracellular matrix structure, low immunogenicity, easy synthesis and modification, and flexible loading capacity provide a highly efficient therapeutic platform for bone tissue repair.Herein, we discuss the design principles of self-assembled peptide hydrogels, report the structural characteristics and assembly mechanisms of self-assembled peptides, and highlight recent advances in self-assembled peptide hydrogels for bone regeneration, including delivery to cells , bone morphogenetic proteins, active factors and small molecular substances.Finally, the bottleneck and development direction of self-assembled peptide hydrogels are pointed out, aiming to provide guidance for the construction of hydrogel delivery systems with high osteogenic properties.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Practice guideline
Language:
Chinese
Journal:
Journal of China Pharmaceutical University
Year:
2022
Type:
Article
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