Progress of research on multiple myeloma and gut microbiota / 白血病·淋巴瘤

ABSTRACT

Intestinal tract is the main place for nutrient digestion and absorption. Gut microbiota is involved in the regulation of host energy storage, metabolism, immunity an soon, and plays a key role in maintaining the body healthy and inducing tumorigenesis. Multiple myeloma (MM) is a malignant plasma cell disease, while the underlying pathogenesis remains unclear. In recent years, with the continuous understanding of gut microbiota, the mechanism of gut microbiota in the development and progression of MM has been explored gradually. Differences in composition and abundance of gut microbiota can be seen in MM patients under different disease states. Besides, gut microbiota also functions through regulating the metabolites. Gut microbiota may be a potential therapeutic target for MM treatment in the future. This paper reviews the progress of research on MM and gut microbiota.