Mechanisms of recurrence and coping strategies of CD19 chimeric antigen receptor T-cell in treatment of B-cell hematologic neoplasms / 白血病·淋巴瘤

ABSTRACT

Chimeric antigen receptor T-cell (CAR-T) immunotherapy is an effective treatment method in hematologic neoplasms, especially in B-cell hematologic neoplasms. Although a high remission rate is observed clinically, a large number of patients still relapse after CAR-T trerapy. With the wide applications of CAR-T therapy in B-cell tumors and other hematologic malignancies, further clinical research on its mechanisms of recurrence and treatment strategies is needed, in order to improve the clinical efficacy and promote the prognosis of patients.