Immunological effects of type I interferon in systemic lupus erythematosus / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 127-129, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-929818
ABSTRACT
Systemic lupus erythematosus(SLE) is an autoimmune disease with diverse clinical manifestations, and the mechanism of its immune disorder has not been fully defined.Previous studies have shown that type I interferon plays an important role in SLE.Type I interferon is mainly produced by macrophages and dendritic cells, and the interferon-stimulated genes in various immune cells of SLE children were significantly increased.Researchers have found that in addition to interacting with neutrophil extracellular traps, IFN-α can regulate the function of B cells, maintain and amplify autoantibodies, affect the balance of T cell subsets, ultimately aggravate autoimmune abnormalities in SLE patients.Here we review the immunological effects of type I interferon in SLE patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Pediatrics
Year:
2022
Type:
Article
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