The role of respiratory microbiota and mucosal immunity in the pathogenesis of asthma / 国际儿科学杂志

ABSTRACT

Bronchial asthma is a common chronic respiratory disease in children.With the development of high-throughput sequencing technology, it has been found that the occurrence and development of asthma is closely related to the dysbiosis of human microbiome.Studies have shown that the changes of respiratory microbiota can significantly affect the mucosal immune system of the host.Respiratory microbiota may be involved in pathophysiological processes such as airway inflammation, airway hyperresponsiveness and airway remodeling through specific mechanisms in asthma.This review focuses on the relationships between the respiratory microbiota and mucosal immunity, as well as their effects on the pathogenesis of asthma.