Application of platelet-rich fibrin in the treatment of periodontitis / 国际生物医学工程杂志

ABSTRACT

Objective:To explore the effects of platelet-rich fibrin (PRF) on the periodontal soft tissue and bone tissue during the treatment of periodontitis.Methods:Twenty patients with three-wall bone defect of periodontitis requiring periodontal surgery in the Department of Stomatology of the Tianjin First Central Hospital from December 2018 to August 2019 were selected and randomly divided into the experimental group ( n=10) and the control group ( n=10) using the random number table method. For the experimental group, the PRF membrane was covered with Bio-Oss bone. For the control group, only Bio-Oss bone powder was implanted. The image measurement values of probing depth (PD), periodontal attachment level (AL), bleeding index (BI) and bone defect (IBD) were recorded before and 6 months after the operation, and statistical analysis was performed. Results:The measured values of PD, AL and IBD of the two groups after the operation were better than those before the operation (all P<0.05), which indicated that the operation was effective. At 6 months after the operation, the PD and AL of the experimental group were better than those of the control group (all P<0.05). However, BI and IBD had no statistical significance between the two groups (all P>0.05). Conclusions:The combined use of PRF membrane during periodontal bone grafting can effectively reduce PD and obtain more new clinical attachments.