Immunohistochemical Analysis of Cutaneous Pseudolymphoma / 대한피부과학회지
Korean Journal of Dermatology
;
: 198-205, 1999.
Article
in Korean
| WPRIM
| ID: wpr-93004
ABSTRACT
BACKGROUND:
In the skin, it is often difficult to differentiate lymphomas from reactive lymphoid lesions by light microscopic examination.OBJECTIVE:
Our purpose was to determine whether immunologic data obtained from mutine-processed specimens could be used to further objective morphologic interpretations.METHODS:
We conducted an immunohistochcmical staining in 44 cases of benign and malignant cutaneous lymphoproliferative lesions using nine antibodies, including anti-CD3, UCHL1, MT1, MT2, L26, MB2, BerH2, 123C3, and MIB1.RESULTS:
1. Immunophenotyping with anti-CD3, UCHL1, MT1, L26, and MB2 was useful for the diagnosis of T cell or B cell lymphoma. However, these antibodies showed a lack of specificity for neoplastic cells, 2. Antibody to CD56, 123C3 showed positivity in 4 cases of angiocentric lymphoma, but negativity in 8 cases showing angiocentric lymphoma-like pathology. 3. Antibody to CD30, BerH2 showed positivity in all 6 cases of CD30 positive large cell lymphoma, but negativity in 6 cases showing diffuse lymphoma-like pathology. 4. Antibody to Ki-67, MIB1 showed positivity in more than 30% of infiltrating cells in 6 cases of angiocentric lymphoma, 4 cases of diffuse B cell lymphoma, and in more than 60% of infiltrating cells in 6 cases of CD30 positive large cell lymphoma.CONCLUSION:
These observations suggest that immunostaining may provide useful adjunctive information in distinguishing benign from malignant cutaneous lymphoproliferations in paraffin sections.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraffin
/
Pathology
/
Skin
/
Immunophenotyping
/
Lymphoma, B-Cell
/
Sensitivity and Specificity
/
Pseudolymphoma
/
Diagnosis
/
Lymphoma
/
Antibodies
Type of study:
Diagnostic study
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
1999
Type:
Article
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