Research progress of metformin in tumor immunotherapy / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 292-295, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-930082
ABSTRACT
In recent decades, immune checkpoint inhibitors (ICIs) have ushered in a new era in oncology treatment. Despite the remarkable efficacy of ICIs, there are still many patients who do not benefit from immunotherapy alone. Combination therapy is currently the main research direction in China and abroad. Metformin can enhance the number and function of T cells, affect macrophage polarization, promote natural killer cell activation and regulate immune checkpoint expression. A large number of preclinical and clinical studies are exploring the efficacy and safety of ICIs in combination with metformin in different tumors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2022
Type:
Article
Similar
MEDLINE
...
LILACS
LIS