Research progress of different tumor-infiltrating lymphocyte subtypes in triple-negative breast cancer / 中华内分泌外科杂志

ABSTRACT

Triple-negative breast cancer is considered to be the most aggressive subtype of breast cancer. Due to its lack of expression of estrogen receptor (ER) , progesterone receptor (PR) and HER-2, there is still a lack of clear prognostic judgments and biomarkers that guide treatment. With the development of tumor immunology, the relationship between tumor immune microenvironment and tumor occurrence and development has gradually gained attention. More and more evidence suggests that the higher the level of tumor-infiltrating lymphocytes (TIL) infiltration in triple-negative breast cancer lesions, the better the prognosis of patients. However, TIL is not a single type of cell, and its different lymphocyte subpopulations have different prognostic effects in patients with triple-negative breast cancer. This article summarizes the relationship between different immune cell subgroups in the tumor immune microenvironment and the prognosis of TNBC patients.