Research progress on the incidence and metastasis of breast cancer promoted by obesity in postmenopausal women / 中华内分泌外科杂志

ABSTRACT

To study the correlation between obesity and breast cancer incidence and progression in postmenopausal female, and provide theoretical instruction for breast cancer prevention and treatment, through being based on literature retrieval platforms such as Pubmed and CNKI, integrating multiple domestic and foreign related documents and various studies, it is found that obesity is one of the most important risk factors for breast cancer incidence and progression in postmenopausal women. On one hand, elevated postmenopausal estrogen levels in obese people directly promote the tumor behavior of breast cancer cells; on the other hand, adipose tissue privides a convenient immune environment for tumor growth by releasing inflammatory mediators, which indirectly promotes tumor development. In addition, obesity also induces the differentiation of adipose stem cell (ASCs) into cancer-associated fibroblasts (CAFs) and enhances the proliferation and invasive potential of breast cancer cells. As mentioned above, obesity increases the risk of breast cancer tumorigenesis and metastasis in postmenopausal women, and increases the risk of cancer-related death in breast cancer patients. The review elaborates the correlation between obesity and breast cancer incidence and progression in postmenopausal women, to provide new ideas for the prevention and treatment of breast cancer, which has essential clinical research value.