Mechanism of hepatocyte growth factor in childhood respiratory diseases / 中华实用儿科临床杂志

ABSTRACT

Hepatocyte growth factor (HGF) is a mesenchymal-derived growth factor, which is widely used in the basic and clinical research of pediatric multi-system due to various biological functions.As a protective factor for lung tissues, HGF has significant biological effects on enhancing lung tissue development, stimulating DNA production of lung epithelial cells, repairing lung microvascular endothelial cells, inhibiting apoptosis induced by lung injury, and delaying pulmonary fibrosis.HGF is closely related to the occurrence and development of respiratory diseases in children.This study aims to review the physiological characteristics of HGF and the mechanism in children′s respiratory diseases.