Research advances on exosome-derived microRNA related to treatment of cardiovascular diseases in children / 中华实用儿科临床杂志

ABSTRACT

In recent years, exosomes have been gradually concerned, and exosome-derived microRNA (exo-microRNA) have been widely used in the early diagnosis as non-invasive biomarkers with a great potential.There are abundant exosomes in the blood released by platelets, arterial endothelial cells and other cell types, and the external membrane of exosomes also has the unique advantages of protecting exo-microRNA and other contents from biological enzyme hydrolysis and stabilizing them in human body fluids.Therefore, exosomes and exo-microRNA are of great significance in the early diagnosis of cardiovascular diseases, cell regeneration, and cardiac protection.This review focuses on the structure and biogenesis of exosomes, the mechanism of exo-microRNA, and the relevant research progress of exo-microRNA in treatment of pediatric cardiovascular diseases in recent years.