Configuration and the safe use of standardized parenteral nutrient solution for preterm infants / 中国新生儿科杂志

ABSTRACT

Objective:To study the configuration and safety of standardized parenteral nutrition solution for premature infants.Methods:A retrospective cohort study was used to the premature infants who were admitted to the neonatal intensive care unit of the West China Second Hospital within 24 hours after birth, 28~34 weeks gestational age, and began parenteral nutrition within 48 hours after birth from June 2015 to November 2018. Electrolytes, blood sugar, phlebitis and venous catheter-related infection during the use of parenteral nutrient fluids were collected, and divided into standardized parenteral nutrient solution group and individualized parenteral nutrient solution group according to the types of parenteral nutrient fluids used. Data analysis is realized by using EmpowerStats statistical software based on R language.Results:A total of 840 premature infants were collected, among them, 541 cases of standardized parenteral nutrition solution group and 299 cases of individual parenteral nutrition solution group. Compared with the individual parenteral nutrition solution group, the incidence of hyperglycemia was 6.3% (34/541) vs. 21.7% (65/299), OR=0.491, 95% CI 0.268~0.899. The incidence of hypokalemia was 13.5% (73/541) vs. 59.9% (179/299), OR=0.137, 95% CI 0.090~0.208. The incidence of hypercalcemia was 25.9% (140/541) vs. 62.8% (188/299), OR=0.249, 95% CI 0.162~0.383. The incidence of hypophosphatemia was 0.2% (1/541) vs. 2.7% (8/299), OR=0.076, 95% CI 0.008~0.686. All the differences were statistically significant ( P<0.05) .There was no significant difference in the incidence of catheter-related infections between the two groups ( P>0.05). Conclusions:Standardized parenteral nutrition is safer in maintaining blood glucose, blood potassium and calcium and phosphorus metabolism in premature infants.