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Single nucleotide polymorphisms in risk genes of restless legs syndrome: a Meta-analysis / 中华行为医学与脑科学杂志
Chinese Journal of Behavioral Medicine and Brain Science ; (12): 187-192, 2022.
Article in Chinese | WPRIM | ID: wpr-931922
ABSTRACT

Objective:

To investigate the correlation between single nucleic acid polymorphisms (SNPs) of MEIS1, BTBD9, MAP2K5, PTPRD and restless leg syndrome (RLS).

Methods:

By searching the literatures published before March 1, 2021 at home and abroad, case-control studies on risk genes associated with RLS were collected, and the Review Manager 5.3 and Stata 15.1 softwares were used for statistical analysis.

Results:

A total of 8 studies were included, with a total of 7 824 cases and 14 645 controls.Meta analysis results showed that the SNPs locus of the risk gene associated with RLS was MEIS1 rs2300478( OR=1.68, 95% CI 1.59-1.78), BTBD9 rs9296249( OR=1.62, 95% CI 1.47-1.77), BTBD9 rs9357271( OR=1.49, 95% CI 1.44-1.55), MAP2K5 rs12593813( OR=1.44, 95% CI 1.36-1.53), MAP2K5 rs11635424( OR=1.47, 95% CI 1.34-1.60)and PTPRD rs1975197( OR=1.34, 95% CI 1.21-1.49).

Conclusion:

MEIS1 rs2300478, BTBD9 rs9296249, BTBD9 rs9357271, MAP2K5 rs12593813, MAP2K5 rs11635424 and PTPRD rs1975197 are the risk loci of RLS.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study / Observational study / Risk factors / Systematic reviews Language: Chinese Journal: Chinese Journal of Behavioral Medicine and Brain Science Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study / Observational study / Risk factors / Systematic reviews Language: Chinese Journal: Chinese Journal of Behavioral Medicine and Brain Science Year: 2022 Type: Article