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Effect of acute hypoxemia on central venous pressure in patients with respiratory failure / 中国医师杂志
Journal of Chinese Physician ; (12): 383-386, 2022.
Article in Chinese | WPRIM | ID: wpr-932074
ABSTRACT

Objective:

To examine the influence of acute hypoxemia on central venous pressure (CVP) and diastolic blood pressure (DBP) in critical patients assisted by mechanical ventilation.

Methods:

We retrospectively analyzed the clinical data of critical patients assisted by mechanical ventilation in Medical Information Mart for Intensive Care Ⅲ (MIMIC-Ⅲ) database. Influence of acute hypoxemia on CVP and diastolic blood pressure (DBP) were evaluated. Hypoxemia was defined according to oxygenation index (OI) (OI≤100 as severe, 100<OI≤200 as moderate). Two cutoff values were set at OI=100 and OI=200. The primary outcomes were the difference between mean CVP, mean DBP 6 hours after the onset of hypoxemia and 6 hours before the event.

Results:

Among all critical patients assisted by mechanical ventilation, 508 patients met criteria of severe hypoxemia, and 1 117 patients met criteria of moderate hypoxemia. After adjusting positive expiratory end pressure (PEEP) and heart rate by multiple linear regression, CVP in patients with moderate and severe hypoxia increased significantly during the observation window of acute hypoxemia ( P=0.04, 0.02), but DBP did not change significantly ( P=0.29, 0.31).

Conclusions:

Acute hypoxemia could increase CVP and probably pulmonary circulation resistance in respiratory failure patients.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Chinese Physician Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Chinese Physician Year: 2022 Type: Article