A Case of Microscopic Polyangiitis with Pulmonary Hemorrhage and Rapidly Progressive Glomerulonephritis
Journal of the Korean Society of Pediatric Nephrology
;
: 213-218, 2001.
Article
in Korean
| WPRIM
| ID: wpr-93228
ABSTRACT
Microscopic Polyangiitis(MPA) belongs to a spectrum of systemic vasculits, and particularly antineutrophil cytoplasmic autoantibodies(ANCA)-associated small-vessel vasculitis which is characterized by involvement of the lung and kidney. The diagnosis of MPA is often difficult to make, and delayed because of the variability of the clinical presentation. Renal biopsies have a very important diagnostic and prognostic value in MPA. We experienced a case of microscopic polyangiits which was confirmed by renal biopsy and positive serum perinuclear ANCA, associated with alveolar hemorrhage and gastrointestinal bleeding. We began methylprednisolone pulse therapy, combined with a low dose of cyclophosphamide and plasmapheresis therapy. ACE inhibitor and Ca channel blocker were used when proteinuria and hypertention developed. On admission, the patient's lab findings showed BUN 117 mg/dL, Cr 2.3 mg/dL, while on the 60th hospital day BUN/Cr values fell to 20.8 mg/dL / 1.6 mg/dL and though proteinuria persisted, the patient's condition was tolerable and is currently under observation on an out-patient basis. The last lab values were BUN 26 mg/dL / Cr 1.6 mg/dL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Outpatients
/
Proteinuria
/
Vasculitis
/
Biopsy
/
Methylprednisolone
/
Plasmapheresis
/
Antibodies, Antineutrophil Cytoplasmic
/
Cyclophosphamide
/
Cytoplasm
/
Diagnosis
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Pediatric Nephrology
Year:
2001
Type:
Article
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