The prognostic significance and treatment modality for elevated pre- and postoperative serum CEA in colorectal cancer patients
Annals of Surgical Treatment and Research
; : 165-171, 2016.
Article
in En
| WPRIM
| ID: wpr-93259
Responsible library:
WPRO
ABSTRACT
PURPOSE: The purpose of this study was to evaluate the prognostic significance of serum CEA (s-CEA) changes in colorectal cancer (CRC) patients with sustained elevated postoperative s-CEA levels. METHODS: Between January 1999 and December 2008, 9,380 CRC patients underwent surgery. Curative resection was performed in 1,242 CRC patients with high preoperative s-CEA levels (>6 ng/mL). High s-CEA levels were normalized in 924 patients (74.4%) within 2 weeks from surgery, whereas high s-CEA levels were persistent in 318 patients (25.6%). Patients were divided into 2 groups according to their postoperative s-CEA levels: group 1 (37 patients with a 1-year postoperative s-CEA>6 ng/mL) and group 2 (281 patients with a 1-year postoperative s-CEA≤6 ng/mL). RESULTS: A postoperative recurrence was identified in 24 patients (64.9%) in group 1 and 65 patients (23.1%) in group 2 (P < 0.001). A curative resection after recurrence was performed in 22 patients (33.8%) from group 2, but no patients from group 1 (P = 0.001). The 5-year overall survival and time to recurrence were significantly lower in patients with recurrent cancer in group 1 (P < 0.001). CONCLUSION: Patients with persistent elevated postoperative s-CEA levels are at high risk for recurrence and a low survival rate. More intensive surveillance of patients with high postoperative s-CEA levels should be mandatory.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Recurrence
/
Colorectal Neoplasms
/
Survival Rate
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Annals of Surgical Treatment and Research
Year:
2016
Type:
Article