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Research progress in the role of TRPV channel-induced Ca 2+ signal in osteoclast differentiation and bone resorption / 中华骨科杂志
Chinese Journal of Orthopaedics ; (12): 668-674, 2022.
Article in Chinese | WPRIM | ID: wpr-932879
ABSTRACT
Osteoclast is a type of multinuclear giant cell, which plays a role in bone resorption in the homeostasis of bone mass. Excessive bone resorption leads to osteoporosis and other diseases characterized by decreased bone mass. Ca 2+ metabolism plays an important role as a second messenger in the differentiation, migration, fusion and bone resorption of osteoclast. The transient receptor potential vanilloid (TRPV) ion channel is expressed in a variety of cells, including osteoclast. Current studies have found that the TRPV ion channel can participate in the production and bone resorption function of osteoclast by increasing intracellular Ca 2+ concentration and calcium oscillations. This article reviews the relationship between the TRPV ion channel and the changes of Ca 2+ concentration and the potential mechanisms involved in osteoclast activity, so as to provide a reference for further research on diseases characterized by abnormally increased activation of osteoclast in the future.
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Orthopaedics Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Orthopaedics Year: 2022 Type: Article