Progress of research on the relationship between Parkinson's disease and osteoporosis in hypoxic environments / 中华老年医学杂志

ABSTRACT

Parkinson's disease is a progressive neurodegenerative disorder often seen in the elderly and seriously affects patients' quality of life.Osteoporosis is also a common systemic metabolic bone disease in the elderly characterized by a predisposition to fractures.Studies have shown that Parkinson's disease is highly correlated with osteoporosis, and patients with Parkinson's disease are at high risk for osteoporosis.Hypoxic environments may aggravate the disease and its complications in patients with Parkinson's disease, and the possible mechanisms may involve inhibition of growth and differentiation of osteoblasts, promotion of the formation of osteoclasts, and thus increased risk of osteoporosis under hypoxic conditions.Recent studies have reported that hypoxia, low air pressure, strong sunlight exposure and diets are associated with Parkinson's disease and osteoporosis at high altitudes.This paper reviews research progress on the relationship between Parkinson's disease and osteoporosis in hypoxic environments.