Effect of esketamine-based anesthesia on postoperative psychological distress in patients undergoing radical resection of lung cancer / 中华麻醉学杂志

ABSTRACT

Objective:To evaluate the effect of esketamine-based anesthesia on postoperative psychological distress in the patients undergoing radical resection of lung cancer.Methods:From December 2019 to November 2020, 121 patients (male or female), aged 18-75 yr, with body mass index of 18.5-24.9 kg/m 2, of American Society of Anesthesiologists physical status Ⅰ-Ⅲ, underwent radical resection of lung cancer in our hospital, were divided into 2 groups by a random number table method: control group (group C, n=60) and esketamine combined anesthesia group (group EK, n=61). Combined intravenous-inhalational anesthesia was used in both groups.In EK group, esketamine 0.5 mg/kg was intravenously injected before skin incision, and esketamine was continuously infused at a rate of 0.5 mg·kg -1·h -1 during surgery and then adiministration was discontinued at 30 min before the end of surgery.In EK group, esketamine was continuously infused at a rate of 0.2 mg·kg -1·h -1 for postoperative analgesia, lasting for 48 h. Postoperative analgesia was performed with sufentanil 100 μg+ ketorolac tromethamine 120 mg+ droperidol 2.5 mg (100 ml in total) in both groups, with background infusion 2 ml/h, bolus dose 2 ml and lockout interval 15 min.The patients were assessed using a psychological distress thermometer at 7 days and 1 month after surgery, and distress thermometer≥4 was defined as psychological distress.The occurrence of pain was recorded, and the occurrence of adverse reactions within 3 days after surgery was recorded. Results:Compared with group C, the incidence of psychological distress was significantly decreased at 7 days and 1 month after operation in group EK ( P<0.05). There was no significant difference in the incidence of adverse reactions within 3 days after operation between the two groups ( P>0.05). Conclusions:Esketamine-based anesthesia can decease the occurrence of psychological distress after radical resection of lung cancer in the patients.