The Effect of Gd-EOB-DPTA on the Stiffness Value of Magnetic Resonance Elastography in Evaluating Hepatic Fibrosis
Journal of the Korean Society of Magnetic Resonance in Medicine
;
: 215-223, 2013.
Article
in English
| WPRIM
| ID: wpr-93359
ABSTRACT
PURPOSE:
To evaluate the effect of gadoxetic acid on the measurement of the stiffness value of MR elastography (MRE) used to evaluate hepatic fibrosis (HF). MATERIALS ANDMETHODS:
MRE was obtained in 32 patients with clinically suspected chronic liver disease, both before and after injection of gadoxetic acid. Two independent reviewers measured the stiffness values of the liver parenchyma on elastograms. The mean liver stiffness values were compared in the pre- and post-contrast MREs using the paired t-test. Intra-rater and inter-rater correlation was assessed using the intraclass correlation coefficient (ICC). The accuracy, sensitivity, and specificity of both pre- and post-contrast MREs was evaluated for the diagnosis of significant HF (> or = F2) using cut off value of 3.1 kPa.RESULTS:
There were no significant differences in the stiffness values of the liver parenchyma on pre- and post-contrast MREs (p = 0.15 and 0.38 for each reader, respectively). Regarding intra-rater correlation, excellent agreement was noted on rater 1(ICC = 0.998) and rater 2 (ICC = 0.996). Excellent correlation regarding the measured stiffness values was noted on both pre- and post-contrast MREs (ICC = 0.988 for pre-contrast, ICC = 0.993 for post-contrast). The accuracy, sensitivity, and specificity of the pre- and post-contrast MREs for differentiating significant HF (> or = F2) from < or = F1 were same as 71%, 60%, and 100%, respectively.CONCLUSION:
As there was no significant difference in the stiffness measurements seen on MREs before and after administration of gadoxetic acids, it is therefore acceptable to perform MRE after contrast injection in order to evaluate HF.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Fibrosis
/
Magnetic Resonance Spectroscopy
/
Sensitivity and Specificity
/
Gadolinium DTPA
/
Elasticity Imaging Techniques
/
Magnets
/
Liver
/
Liver Diseases
/
Magnetics
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Journal of the Korean Society of Magnetic Resonance in Medicine
Year:
2013
Type:
Article
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