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Immunoregulatory effects of leptin on inflammatory bowel disease / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology ; (12): 68-72, 2022.
Article in Chinese | WPRIM | ID: wpr-934015
ABSTRACT
Inflammatory bowel disease (IBD) is a chronic and recurrent disease characterized by chronic inflammation of the gastrointestinal tract. The quality of life of patients with IBD is seriously affected. The pathogenesis of IBD is complex, among which immune factors are considered to be the predominant factor. Leptin is a hormone derived from adipocytes and recent studies have shown that it is involved in the regulation of immune cells and inflammatory signaling pathways. This review summarized the pathogenesis of IBD, the immunoregulatory mechanism of leptin and research progress in immune modulators, introduced the potential effects of leptin on the regulation of immunological homeostasis in IBD and its potential roles in the etiology and pathogenesis of IBD, and discussed a possible immunotherapy method to treat IBD through leptin antagonist to reduce the inflammatory response and inhibit the inflammatory signaling pathways.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Microbiology and Immunology Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Microbiology and Immunology Year: 2022 Type: Article