Glycosylation: new era for diseases biomarkers / 中华检验医学杂志

ABSTRACT

Glycosylation is one of the most important posttranslational modification (PTM) for proteins. Glycans of glycoproteins play pivotal effects in cell recognition, signal transduction, differentiation, proliferation and immigration. The sialylation, fucosylation and degree of branching are intimately related to the development and progression of various malignancies and autoimmune diseases. Both glycans as well as glycoprotein have become the hot targets for disease biomarker exploration and therapeutic interventions.