Application of IgG sialylation in the diagnosis and therapy of autoimmune diseases / 中华检验医学杂志

ABSTRACT

Glycosylation is a part of the structure and function of immunoglobulin G (IgG). Sialic acid is located at the end of IgG N-glycan and regulates IgG anti-inflammatory and pro-inflammatory activities by changing the binding of IgG with fragment crystallizable gamma receptors (FcγRs) and complements. Low IgG sialylation is closely related to the occurrence, development and prognosis of autoimmune diseases and shows great potential in the field of diagnosis, monitoring and treatment, and may function as a new biomarker and therapeutic target for autoimmune diseases.