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Correlation between serum IgG N-glycan and Lauren classification of gastric cancer / 中华检验医学杂志
Chinese Journal of Laboratory Medicine ; (12): 373-380, 2022.
Article in Chinese | WPRIM | ID: wpr-934381
ABSTRACT

Objective:

Analyze the correlation between serum immunoglobulin G (IgG) N-glycan and Lauren classification of gastric cancer.

Methods:

A retrospective study was performed on 17 patients with diffuse type gastric cancer and 21 patients with intestinal type who received treatment in Zhongshan Hospital from 2017 to 2018, and the general medical history data and disease characteristics were summarized. The serum IgG glycome profiles were analyzed by ultraperformance liquid chromatography, and the difference between intestinal type and diffuse type gastric cance was compared.Logistic regression was used to evaluate the correlation between serum IgG N-glycan and Lauren classification.

Results:

IgG N-glycome analysis included 27 directly detected glycans and 4 derived traits. H=Hexose, N=N-acetylglucosamine, F=Fucose, S=Sialic acid.There was no significant difference in IgG N-glycan among different chemotherapy protocol. Compared with intestinal type, H3N3F1 ( t=3.785, P=0.001), H3N4( t=3.919, P=0.002), H3N4F1( t=2.770, P=0.005), H3N5F1( t=2.888, P=0.010) were decreased in diffuse type; H4N4F1(6)( t=?3.488, P<0.001), H5N4F1( t=?3.401, P=0.003), H5N5F1( t=?2.303, P=0.023), H5N4F1S1 ( t=?3.068, P=0.008) were increased.H3N3F1( OR1.20, P=0.008), H3N4( OR1.32, P=0.005), H3N4F1 ( OR1.13, P=0.017), H3N5F1 ( OR1.78, P=0.015), H4N4F1(6)( OR0.43, P=0.008), H5N4F1(6)( OR0.74, P=0.008), H5N5F1 ( OR0.32, P=0.036), H5N4F1S1( OR0.48, P=0.009) were significantly correlated with Lauren classification. Sialylated ( t=?2.717, P=0.012) and galactosylated ( t=?3.400, P=0.001) IgG N-glycan were reduced in patients with intestinal type gastric cancer.Galactosylated ( OR0.87, P=0.007) and sialylated ( OR0.62, P=0.015) IgG N-glycan were significantly correlated with Lauren classification.

Conclusion:

Some IgG N-glycan are significantly correlated with Lauren classification, which can be used as potential biomarkers.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Practice guideline / Observational study Language: Chinese Journal: Chinese Journal of Laboratory Medicine Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Practice guideline / Observational study Language: Chinese Journal: Chinese Journal of Laboratory Medicine Year: 2022 Type: Article