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Advances in macrophage immune metabolism of systemic lupus erythematosus / 中华检验医学杂志
Chinese Journal of Laboratory Medicine ; (12): 408-412, 2022.
Article in Chinese | WPRIM | ID: wpr-934387
ABSTRACT
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of large amounts of autoantibodies and the involvement of multiple organs. The polarization imbalance and abnormal activation of macrophages are closely related to the occurrence and development of SLE, and M1 macrophages, specifically, play a pro-inflammatory role in the pathogenesis of SLE. Changes in the immune microenvironment of SLE patients would promote the metabolic reprogramming of macrophages, and induce fluctuations in sugar metabolism, lipid metabolism, and amino acid metabolism, which lead to the accumulation of intermediate metabolites that would act as inflammatory signaling molecules to aggravate the inflammatory response and cause a series of complications. Therefore, a full understanding of the metabolic process of macrophages in SLE will help elucidate the pathogenesis of SLE and lay the foundation for targeted therapy of macrophages.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Laboratory Medicine Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Laboratory Medicine Year: 2022 Type: Article