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Infection and distribution characteristics of HPV of middle-aged and elderly women from a certain hospital in Guangxi Zhuang Autonomous Region from 2018 to 2020 / 中华预防医学杂志
Chinese Journal of Preventive Medicine ; (12): 468-473, 2022.
Article in Chinese | WPRIM | ID: wpr-935310
ABSTRACT

Objectives:

To analyze the type and distribution characteristics of human papillomavirus (HPV) infection along with cervical cytology in middle-aged and elderly women in Guangxi and to provide a basis for the prevention and treatment of cervical cancer in elderly women.

Methods:

21 subtypes of HPV and cervical cytology of women over 45-year-old visiting the First Affiliated Hospital of Guangxi Medical University from January 2019 to December 2020 were collected. They were divided into two groups by age, 45-64 years group and over 65 years group. The HPV, HR-HPV, and multiple HPV infection prevalence were analyzed, as well as HPV genotypes, the age distribution of HPV infection rate, and cervical cytology.

Results:

A total of 6 657 eligible women were included. 6 238 women were in the 45-64 years group, with a HPV prevalence about 20.86% (1 301), while 419 women were in the over 65 years group, with a HPV prevalence about 32.94% (138). The age-associated HPV and HR-HPV prevalence increased with the age, peaking at the age group of 70-74 years (P<0.001). The most prevalent genotype was HPV52, and the infection rate was 5.3% (353), followed by HPV16 and HPV 58, about 4.63% (308) and 3.08% (205) respectively. The majority cytology of HPV-positive middle-aged and elderly women was normal. 8.70% (88) of them were ASC-US, 6.52% (66) for HSIL, 4.55% (46) for LSIL, and 2.96% (30) for ASC-H, and 0.10% (1) for SCC. Compared to middle-aged women, elderly women had a lower negative cytology rate, 69.79% (67) vs. 77.95% (714), but a higher HSIL rate, 13.54% (13) vs. 5.79% (53) (P<0.05).

Conclusions:

HPV and HR-HPV prevalence of elderly women in a medical center of Guangxi are higher than those of middle-aged women. The most prevalent genotype is HPV16 in elderly women, followed by HPV52 and HPV58.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Papillomaviridae / Uterine Cervical Neoplasms / China / Papillomavirus Infections / Human papillomavirus 16 / Hospitals Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Preventive Medicine Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Papillomaviridae / Uterine Cervical Neoplasms / China / Papillomavirus Infections / Human papillomavirus 16 / Hospitals Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Preventive Medicine Year: 2022 Type: Article