Application of phylogenetic analysis in the molecular epidemiological study of infectious diseases / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 282-285, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-935383
ABSTRACT
The rapid development of sequencing technology brings the explosive growth of pathogen genetic data. The combination of genomic data and phylogenetic method is being used to elaborate the origin and evolution of pathogens, the time and space distribution and parameter changes in the prevalence process, and how phenotypes like antigen, virulence, and resistance change over time. This method is also being used to predict pathogen transmission trends. In this study, we described the aim of phylogeny and the process of the phylogenetic construction method. We elaborated the advantages and disadvantages and scope of application of tree-building methods including distance-based, maximum parsimony, maximum likelihood and bayesian methods. We have reviewed the application and the estimation methods of major epidemiological parameters of phylodynamics and phylogeography in domestic and foreign studies. We concluded that the time- and location-scaled phylogenetic trees are increasingly used for outbreak investigation and routine surveillance of infectious diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phylogeny
/
Epidemiologic Studies
/
Communicable Diseases
/
Bayes Theorem
/
Genomics
Type of study:
Observational study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2022
Type:
Article
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