Gene-lifestyle interaction on coronary heart disease in adult twins of China / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 649-654, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-935438
ABSTRACT
Objective:
To explore the gene-lifestyle interaction on coronary heart disease (CHD) in adult twins of China.Methods:
Participants were selected from twin pairs registered in the Chinese National Twin Registry (CNTR). Univariate interaction model was used to estimate the interaction, via exploring the moderation effect of lifestyle on the genetic variance of CHD.Results:
A total of 20 477 same-sex twin pairs aged ≥25 years were recruited, including 395 CHD cases, and 66 twin pairs both had CHD. After adjustment for age and sex, no moderation effects of lifestyles, including current smoking, current drinking, physical activity, intake of vegetable and fruit, on the genetic variance of CHD were found (P>0.05), suggesting no significant interactions.Conclusion:
There was no evidence suggesting statistically significant gene-lifestyle interaction on CHD in adult twins of China.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Twins
/
Twins, Dizygotic
/
Twins, Monozygotic
/
China
/
Coronary Disease
/
Diseases in Twins
/
Life Style
Type of study:
Prognostic study
Limits:
Adult
/
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2022
Type:
Article
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